ZHANG Xinrui, ZHANG Xin, GUAN Jian, MAO Shirui

(School of pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

Abstract: The principle of spray drying，the formation process of particle composition redistribution, solidification and morphology change after solidification，effect of spray drying process on particle properties，and the particle engineering strategies to improve lung deposition of dry powder inhalations，such as aerodynamic diameter, density andsurface hydrophobic treatment were reviewed.It is considered that the main advantage of spray drying in pulmonary drug delivery is to optimize particle properties by manipulating and controlling various parameters，and combined with particle engineering technology and appropriate excipients, ideal spray drying particles can be obtained to maximize the deposition in the lung target site.Optimization of particle aerodynamic diameter, reduction of particle density and surface hydrophobic treatment of particles can make up the disadvantages of spray drying particles in powder fluidity，dispersion and drug stability.

Keywords: particle engineering；spray drying；dry powder inhaler；pulmonary delivery

中图分类号： R944                              文献标志码： A

文章编号：1008-5548(2022)01-0108-12

DOI:10.13732/j.issn.1008-5548.2022.01.012

收稿日期： 2021-09-01，修回日期：2021-10-09，在线出版时间：2021-11-26。

基金项目：国家重点研发计划项目，编号：2020YFE0201700。

第一作者简介：张芯蕊(1998—)，女，硕士研究生，研究方向为干粉吸入剂。E-mail: 335368627@qq.com。

通信作者简介：毛世瑞(1969—)，女，教授，博士生导师，研究方向为生物可降解高分子聚合物作为药物载体、肺部吸入、鼻黏膜递药