HUANG Yongpeng,CHEN Bo,TANG Hui,ZHONG Hui,MENG Xiangyan,JIAO Jianlan

(Research Institute of Chemical Defense,Beijing 102205,China)

Abstract: In this paper,the more uniform and smaller pentoxyverine citrate powder was prepared by an experimental apparatus for supercritical antisolvent process,and the effects of process parameters including pressure,temperature,flow rate and solvent,on the morphology,the particle size and particle size distributions were investigated experimentally. The results show that the morphology of microparticles prepared is all plate. The process parameters have different effects on the particle size and particle size distribution,the pentoxyverine citrate microparticles with the geometric particle size of 0.5～12 μm and the aerodynamic particle size of 1.2 μm can be obtained by adjusting process parameters,and the prepared micropaticles are suitable for inhalation delivery system.

Keywords: inhalation drug delivery; supercritical antisolvent process; microparticles

中图分类号：R238.6                             文献标志码：A

文章编号：1008-5548(2020)01-0046-07

DOI:10.13732/j.issn.1008-5548.2020.01.008

收稿日期： 2019-04-26，修回日期：2019-05-28，在线出版时间：2019-07-23 10:10。

基金项目：国防预先研究项目。

第一作者简介：黄永鹏(1986—)，男，硕士，助理研究员，研究方向为粉体制备与应用。E-mail：380645362@qq.com。

通信作者简介：焦剑岚(1976—)，女，硕士，副研究员，研究方向为分析化学。E-mail：catherinejiao@163.com。