HUANG Yongpeng, CHEN Bo, TANG Hui, ZHONG Hui, MENG Xiangyan, JIAO Jianlan

(Research Institute of Chemical Defense, Beijing 102205, China)

Abstract: In this paper, the polypeptide powder was prepared by an experimental apparatus for supercritical antisolvent process, and the effects of process parameters including pressure, temperature, flow rate and concentration on the particle size were investigated experimentally. The characteristics of the powder were carried out by SEM, TGA and XRD. The results show that there is no signifigant effect of pressure, temperature and concentration on particle size and the morphology of micro-particles prepared is mainly spherical. There is no significant change in the thermal stability of micro-powder. The powder is mainly amorphous structure. The aerodynamic particle size of the powder is about 1.0 μm, which is suitable for inhalation delivery system.

Keywords: inhalation drug delivery; supercritical antisolvent process; polypeptide; microparticles

收稿日期： 2019-09-29，修回日期：2019-11-21，在线出版时间：2019-12-31 09:46。

基金项目：国防预先研究项目，编号：LD4B04。

第一作者简介：黄永鹏(1986—)，男，硕士，助理研究员，研究方向为粉体制备与应用。E-mail：380645362@qq.com。

通信作者简介：焦剑岚(1976—)，女，硕士，副研究员，研究方向为分析化学。E-mail：catherinejiao@163.com。

文章编号：1008-5548(2020)02-0041-07

doi:10.13732/j.issn.1008-5548.2020.02.007

中图分类号：R238.6                              文献标志码：A