DAI Mengmeng, ZHANG Yuanyuan, WANG Shaohua, SHENG Huagang

(School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China)

Abstract: Based on the related research of nanocrystal technology in poorly soluble drugs, the coverage, mechanism, preparation technology and application forms of nanocrystalline drugs are reviewed. Nanocrystalline drug preparation technologies include traditional technologies such as Top-down technology, Bottom-up technology, and new technologies such as Top-down and Bottom-up technology, eutectic technology and Bottom-up technology, and laser crushing technology. The Top-down technology reduces the particle size of the drug particles to nano-sized particles by mechanical force. The Bottom-up technology rapidly reduces the particles by controlling the precipitation or crystallization of the drug particles. The new technology is rapidly becoming an effective supplement to the traditional technology.At present, the research and application of nanocrystal drug preparation technology in the insoluble drug components is in an ascending stage, and the depth and breadth of the research need to be improved.

Keywords:nanocrystals; poorly soluble drugs; Top-down technology; Bottom-up technology

中图分类号：R943.5                               文献标志码：A

收稿日期： 2019-05-19， 修回日期：2019-05-25，在线出版时间：2019-06-21 10:53。

基金项目：山东省优秀中青年科学家科研奖励基金项目，编号：BS2014YY047；山东省医药卫生科技发展计划，编号：2018WS202。

第一作者简介：代孟孟(1996—)，女，硕士研究生，研究方向为中药新剂型与新制剂研究，E-mail：m17862968199@163.com。

通信作者简介：盛华刚(1979—)，男，博士，副教授，硕士生导师，研究方向为中药新剂型与新制剂研究，E-mail：shenghuagang@sina.com。

文章编号：1008-5548(2019)05-0056-07

DOI:10.13732/j.issn.1008-5548.2019.05.010