Abstract：The three-dimensional porous nano-hydroxyapatite was prepared by template method. The effect of aging temperature and the initial pH on the morphology, structures and chemical composites of the hydroxyapatite was investigated. The amoxicillin-hydroxyapatite was prepared using the prepared hydroxyapatite as drug carrier. The effect of the pH of PBS liquid on the drug delivery of amoxicillin-hydroxyapatite was investigated. The result indicates that the calcium phosphate is generated when the aging temperature is lower than 284.16 K and the size of hydroxyapatite is decreased with the aging temperature.When the initial pH is lower than 10.2, calcium phosphate isgenerated, the hydroxyapatite is sheet and its size is 334 nm.When the initial pH is 10.2, it is the pure hydroxyapatite, the hydroxyapatite is rodlike and the size is 134 nm. The result also indicates that amoxicillin-hydroxyapatite has the good sustained-release performance and selective desorption performance, that the desorption efficiency of amoxicillin is48.3% in 1.5 h and the total desorption efficiency is 92.8% in pH 5.7 PBS liquid.

Keywords：three-dimensional porous nano-hydroxyapatite; drug carrier; drug delivery; aging temperature