Abstract：Hi gh drug loading inhalable pentoxyverine citrate coated lactose composite powders were prepared by high pressure homogenization-spray drying process, and their micro scopical morphology, aerodynamic property, inhalation and deposition property were characterized. The results show that the micro scopical morphology of composite powders are 0.5² μm spherical particles, and the drug loading rate is as much as 78.9%. Angle of repose is 29 degrees, mass median aerodynamic diameter is 0.99 μm, aerosol availability is 63.2%, and fine particle fraction is 19.3%. All above properties of composite powders are effective for drug delivery of dry powder inhalers.

Keywords: pentoxyverine citrate; lactose; spray drying; high pressure homogenization