Abstract：Micro-nano particles of model drug pentoxyverine citrate were prepared by anti-solvent or reactive precipitation method. The micromixing of liquid phase precipitation was reinforced by micro-channel or high gravity reactor simultaneously. Properties of particles were analyzed. The results show that it is effective of modified reactors to prepare micro-nano particles by reinforced micromixing. Drug particles exhibit100~200 nm flake crystal and remain stable microstructure. The reinforcement is adapted to anti-solvent precipitation as rapid physical process, and high gravity reactor has the highest preparation efficiency.

Keywords: liquid phase precipitation; micromixing; pentoxyverine citrate; micro-nano particle; modified reactor