Abstract：Pentoxyverine citrate nano-particles were prepared by the method of high pressure homogenization. The effect of homogenization pressure, homogenization times and preservation course on morphology and particle size of medicine particles was discussed. Superfine powders were obtained by spray drying. The results show that homogenization pressure of 75 MPa and five cycles are the optimum parameters. The prepared nano-particles exhibit flake crystals with particle size between 100 and 200 nm and preserve steadily. The pentoxyverine citrate powders spray dried by nano-particle turbid liquid exhibit spherical particles with particle size less than 1 μm, which are agglomerated by flake crystal nano-particles remaining former micro-structure and micro-morphology.

Keywords: high pressure homogenization method; pentoxyverine citrate; nano-particle; spray drying