Abstract：The silica coated with lincomycin(LIN) imprinted polymeric layer(LIN-MIP-PMAA-SiO₂) was prepared by using LIN as template molecule, methacrylic acid as functional monomer and ethylene glycol dimethacrylate as crosslinker, and its structure was conformed by IR and SEM. The adsorption properties of LIN-MIP-PMAA-SiO₂ on lincomycin were also studied. The results show that the maximum static adsorption capacity of LIN-MIP-PMAA-SiO₂ for LIN is 106 mg·g-1and it takes about 220 min to achieve the adsorption equilibrium. The separation factor of LIN-MIP-PMAA-SiO₂ on lincomycin and clindamycin is 1.20, showing that LIN-MIP-PMAA-SiO₂ displayed high recognition ability to the template molecule-LIN.

Keywords: silicone; lincomycin; surface imprinted; adsorption property