LIU Zhigang1a， SUN Lina2 ， WANG Jiangang1a， JIN Gang1b
（1. a. Analysis and Test Center; b. College of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, China; 2. Jilin Xingyun Chemical Co., Ltd., Jilin Chemical Group Corp., Jilin 132022, China）
Abstract： Pioglitazone hydrochloride ultrafine powders were prepared by ultrasound-assisted anti-solvent method. The effect of drug concentration, volume ratio of anti-solvent and solvent, temperature and ultrasound power on the particle morphology and size was investigated in methanol - deionized water system. The as-prepared particles were characterized by techniques of SEM, XRD, IR and DSC. The results indicate that the ultrafine particles of pioglitazone hydrochloride are short fibrous with mean particle size of 250 nm. The crystallinity of particles decreases before and after micronization. But there is no change in the chemical structure of drugs.
Keywords: pioglitazone hydrochloride; anti-solvent method; ultrafine powder
中图分类号：R972+.4 文献标志码：A
文章编号：1008-5548(2015)03-0029-04
DOI:10.13732/j.issn.1008-5548.2015.03.007
收稿日期：2014-07-06， 修回日期：2014-07-10，在线出版时间：2015-06-24。
第一作者简介：刘治刚(1983—)，男，硕士，讲师，研究方向为药物微粉制备及水溶性。 E-mail ：lzg@jlict.edu.cn。
