摘要：为了比较三七普通粉和微粉的粉体学特征、水溶性浸出物含量、指标成分溶出量及溶出速度,探索三七粉碎的临界粒径,通过激光粒度分析仪和扫描电子显微镜对普通粉和微粉进行表征,测定粉体学参数休止角和堆密度,热浸法测定水溶性溶出物的含量,利用小杯溶出法进行指标成分的溶出实验,采用梯度HPLC分析人参皂苷R_g1、R_b1和三七皂苷R₁的含量。结果表明:三七普通粉和微粉的粉体学特征、水溶性浸出物含量差异显著,人参皂苷R_g1、R_b1和三七皂苷R₁的溶出速度微粉较快,但两者在溶出量上无显著差异。微粉化对中药的必要性应结合具体的中药进行研究,三七制备为100目的粉体在体外溶出已达到最适。

关键词：超细粉碎;中药;三七;

Abstract: The powder characteristic, water extraction amount, extractionamount of active ingredients and dissolution rate are comparatively stud-ied between crude powder and micronized powder to get the critical particle size of panax notoginseng. Panax notoginseng powder is characterizedby laser diffraction analyzer and scanning electron microscopy, the angleof repose and bulk density is measured, the water extraction is quantified byheated Extractiong method, the active ingredients R_g1, R_b1 and R₁ are de-tected by gradient HPLC after they released from panax notoginseng. Thedifferences of particle characteristics and water extraction amount between crude powder and superfine are significant, the dissolution rate ofactive ingredients R_g1, R_b1 and R₁ are faster, and the dissolution amount arealmost the same. Micronization technology is applied or not to the Chinesetraditional medicine according to study, 100 mesh is the optimal size ofpanax notoginseng.

Key words: micronization; panax notoginseng; the Chinese traditionalmedicine