摘要：采用反溶剂和反应沉淀方法, 利用微通道反应器和超重力反应器强化液相沉淀微观混合, 制备模型药物枸橼酸喷托维林纳微颗粒并分析颗粒性质。结果表明:新型反应器能够通过强化液相沉淀微观混合制备得到药物纳微颗粒, 颗粒为片状结晶, 粒径在100~200 nm, 制备过程中药物微观物相结构未发生改变;其中反溶剂沉淀为快速物理过程, 适于强化微观混合, 超重力反应器具有最高的制备效率。

关键词：液相沉淀；微观混合；枸橼酸喷托维林；纳微颗粒；新型反应器

Abstract：Micro-nano particles of model drug pentoxyverine citrate were prepared by anti-solvent or reactive precipitation method. The micromixing of liquid phase precipitation was reinforced by micro-channel or high gravity reactor simultaneously. Properties of particles were analyzed. The results show that it is effective of modified reactors to prepare micro-nano particles by reinforced micromixing. Drug particles exhibit100~200 nm flake crystal and remain stable microstructure. The reinforcement is adapted to anti-solvent precipitation as rapid physical process, and high gravity reactor has the highest preparation efficiency.

Keywords: liquid phase precipitation；micromixing；pentoxyverine citrate；micro-nano particle；modified reactor