摘要：以纳米晶体技术在难溶性药物中的相关研究为出发点,综述纳米晶体药物的涵盖范围、作用机制、制备技术和应用形式。纳米晶体药物的制备技术包括传统技术即Top-down技术、Bottom-up技术以及新型技术即Topdown和Bottom-up技术联用、共晶技术和Bottom-up技术联用、激光破碎技术等。Top-down技术通过机械力将粒径较大的药物颗粒减小为纳米尺寸的颗粒,Bottom-up技术通过控制药物颗粒沉淀或结晶使颗粒迅速减小,新型技术作为传统技术的有效补充发展迅速。目前纳米晶体药物制备技术在难溶性药物成分中的研究与应用处于上升阶段,研究的深度和广度有待于提高。

Abstract: Based on the related research of nanocrystal technology in poorly soluble drugs，the coverage，mechanism， preparation technology and application forms of nanocrystalline drugs are reviewed．Nanocrystalline drug preparation technologies include traditional technologies such as Top-down technology，Bottom-up technology，and new technologies such as Top-down and Bottom-up technology，eutectic technology and Bottom-up technology，and laser crushing technology．The Top-down technology reduces the particle size of the drug particles to nano-sized particles by mechanical force．The Bottom-up technology rapidly reduces the particles by controlling the precipitation or crystallization of the drug particles．The new technology is rapidly becoming an effective supplement to the traditional technology．At present，the research and application of nanocrystal drug preparation technology in the insoluble drug components is in an ascending stage，and the depth and breadth of the research need to be improved．

Keywords: nanocrystals; poorly soluble drugs; Top-down technology; Bottom-up technology